Will fan favorite Jo-Wilfried Tsonga make his second career grand slam semifinal tonight against Novak Djokovic? A definite maybe. (Photo by: Getty Images/Scott Barbour)

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In all three singles quarterfinals Tuesday that involved seeds, the higher seed lost.  Will upsets remain the M.O. on the second day of quarterfinal action?

Women's Top Half Quarterfinals:

Li Na (CHN)[16] v. Venus Williams (USA) [6] -- I have a real tough time getting any sort of read whatsoever on what will happen in this one.  Li won the only matchup between the two, in the quarterfinals of the Beijing Olympics, which was the biggest event of her life.  But on paper this isn't the type of player who should trouble Venus, as she usually has a tougher time against backboard types than erratic, go-for-broke shotmakers.  Venus really seemed to have reached a new gear late in her match against Schiavone, so I'll go with her because I have to pick somebody.  But really, I have no clue.  Prediction: Venus in 3.

Serena Williams (USA)[1] v. Victoria Azarenka (BLR)[7] -- If you've seen Serena play during this tournament, you'll pick her to win every match she has left.  Azarenka does come off an emotional comeback victory over Zvonareva in the fourth round, and she was the player who pushed Serena to the brink of defeat in last year's tournament before falling ill.  Azarenka will make the second set interesting, I think, but I don't think she'll win it.  Prediction: Serena in 2.

Men's Top Half Quarterfinals:

Roger Federer (SUI)[1] v. Nikolay Davydenko (RUS)[6] -- As I said in my Day 8 recap, this matchup was a whole lot more interesting before Davydenko stunk up the joint against Verdasco.  Davydenko has won two in a row against Federer, but Grand Slam Federer is another beast altogether.  I think Roger will be making it an unbelievable 23 straight grand slam semifinals tonight. Prediction: Federer in 3.

Novak Djokovic (SRB)[3] v. Jo-Wilfried Tsonga (FRA)[10] -- This one will be exciting, but I can't imagine it will be pretty.  Novak Djokovic has not been perfect against his cupcake draw of Gimeno-Traver - Chiudinelli - Istomin - Kubot, but he hasn't needed to be.  Tsonga has been tested, but in matches where he probably shouldn't have been.  These two played in the only Federerless Grand Slam final of the last eighteen, and it was a pretty good match.  With no real usable sample of recent play from either, I'll go with Djokovic because he's the better player.  Crazy, I know.  Prediction: Djokovic in 4.